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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response.
Bland, Philip; Saville, Harry; Wai, Patty T; Curnow, Lucinda; Muirhead, Gareth; Nieminuszczy, Jadwiga; Ravindran, Nivedita; John, Marie Beatrix; Hedayat, Somaieh; Barker, Holly E; Wright, James; Yu, Lu; Mavrommati, Ioanna; Read, Abigail; Peck, Barrie; Allen, Mark; Gazinska, Patrycja; Pemberton, Helen N; Gulati, Aditi; Nash, Sarah; Noor, Farzana; Guppy, Naomi; Roxanis, Ioannis; Pratt, Guy; Oldreive, Ceri; Stankovic, Tatjana; Barlow, Samantha; Kalirai, Helen; Coupland, Sarah E; Broderick, Ronan; Alsafadi, Samar; Houy, Alexandre; Stern, Marc-Henri; Pettit, Stephen; Choudhary, Jyoti S; Haider, Syed; Niedzwiedz, Wojciech; Lord, Christopher J; Natrajan, Rachael.
Afiliação
  • Bland P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Saville H; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Wai PT; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Curnow L; Division of Cancer Biology, The Institute of Cancer Research, London, UK.
  • Muirhead G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Nieminuszczy J; Division of Cancer Biology, The Institute of Cancer Research, London, UK.
  • Ravindran N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • John MB; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Hedayat S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Barker HE; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Wright J; Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
  • Yu L; Division of Cancer Biology, The Institute of Cancer Research, London, UK.
  • Mavrommati I; Division of Cancer Biology, The Institute of Cancer Research, London, UK.
  • Read A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Peck B; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Allen M; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Gazinska P; Translational Cancer Metabolism Team, Centre for Tumour Biology, Barts Cancer Institute, Cancer Research UK Centre of Excellence, Queen Mary University of London, Charterhouse Square, London, UK.
  • Pemberton HN; Biological Services Unit, The Institute of Cancer Research, London, UK.
  • Gulati A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Nash S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Noor F; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK.
  • Guppy N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Roxanis I; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK.
  • Pratt G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Oldreive C; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Stankovic T; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Barlow S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Kalirai H; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
  • Coupland SE; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Broderick R; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Alsafadi S; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
  • Houy A; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
  • Stern MH; Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.
  • Pettit S; Division of Cancer Biology, The Institute of Cancer Research, London, UK.
  • Choudhary JS; Inserm U830, PSL University, Institut Curie, Paris, France.
  • Haider S; Inserm U830, PSL University, Institut Curie, Paris, France.
  • Niedzwiedz W; Inserm U830, PSL University, Institut Curie, Paris, France.
  • Lord CJ; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Natrajan R; The Cancer Research UK Gene Function Laboratory, The Institute of Cancer Research, London, UK.
Nat Genet ; 55(8): 1311-1323, 2023 08.
Article em En | MEDLINE | ID: mdl-37524790
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Poli(ADP-Ribose) Polimerases / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Nat Genet Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Poli(ADP-Ribose) Polimerases / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Nat Genet Ano de publicação: 2023 Tipo de documento: Article