The development of folate-functionalised palladium nanoparticles for folate receptor targeting in breast cancer cells.
Nanotechnology
; 34(46)2023 Aug 29.
Article
em En
| MEDLINE
| ID: mdl-37527629
ABSTRACT
Folate receptor-targeted therapy has excellent prospects for the treatment of breast cancer. A non-toxic concentration of folate-conjugated palladium-based nanoparticles was used to target the overexpressed folate receptor on breast cancer cells. The folate-conjugated nanoparticles were tailored to accumulate selectively in cancer cells relative to normal cells via the folate receptor. The MDA-MB-231, MDA-MB-468, MCF-7 breast cancer cell lines, and MCF-10A normal cell lines were used in the study. Qualitative and quantitative analysis of nanoparticle cellular uptake and accumulation was conducted using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. The findings proved that folate-conjugated palladium nanoparticles successfully and preferentially accumulated in breast cancer cells. We conclude that folate-conjugated palladium nanoparticles can be potentially used to target breast cancer cells for radiopharmaceutical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Nanopartículas
/
Nanopartículas Metálicas
Tipo de estudo:
Qualitative_research
Limite:
Female
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Humans
Idioma:
En
Revista:
Nanotechnology
Ano de publicação:
2023
Tipo de documento:
Article