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Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
Novotna, Katerina; Thomas, Ajit G; Stepanek, Ondrej; Murphy, Brennan; Hin, Niyada; Skacel, Jan; Mueller, Louis; Tenora, Lukas; Pal, Arindom; Alt, Jesse; Wu, Ying; Paule, James; Rais, Rana; Slusher, Barbara S; Tsukamoto, Takashi.
Afiliação
  • Novotna K; Johns Hopkins Drug Discovery, United States; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic V.v.i., Prague, 166 00, Czech Republic; Department of Organic Chemistry, Charles University, Prague, 128 00, Czech Republic.
  • Thomas AG; Johns Hopkins Drug Discovery, United States.
  • Stepanek O; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States.
  • Murphy B; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States.
  • Hin N; Johns Hopkins Drug Discovery, United States.
  • Skacel J; Johns Hopkins Drug Discovery, United States.
  • Mueller L; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States.
  • Tenora L; Johns Hopkins Drug Discovery, United States; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic V.v.i., Prague, 166 00, Czech Republic.
  • Pal A; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States.
  • Alt J; Johns Hopkins Drug Discovery, United States.
  • Wu Y; Johns Hopkins Drug Discovery, United States.
  • Paule J; Johns Hopkins Drug Discovery, United States.
  • Rais R; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States.
  • Slusher BS; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States.
  • Tsukamoto T; Johns Hopkins Drug Discovery, United States; Department of Neurology, United States; Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, United States. Electronic address: ttsukamoto@jhmi.edu.
Eur J Med Chem ; 259: 115674, 2023 Nov 05.
Article em En | MEDLINE | ID: mdl-37536209
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingomielina Fosfodiesterase / Aminas Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esfingomielina Fosfodiesterase / Aminas Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article