Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-&#954;B/NLRP3 pathway.

Liu, Zheng; Huang, Xing; Guo, Hong-Yan; Zhang, Lu-Wen; Quan, Yin-Sheng; Chen, Fen-Er; Shen, Qing-Kun; Quan, Zhe-Shan

Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway.

Liu, Zheng; Huang, Xing; Guo, Hong-Yan; Zhang, Lu-Wen; Quan, Yin-Sheng; Chen, Fen-Er; Shen, Qing-Kun; Quan, Zhe-Shan.

Afiliação

Liu Z; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Huang X; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Guo HY; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Zhang LW; Department of Functional Science, College of Medicine, Yanbian University, Yanji, Jilin, 133002, China.
Quan YS; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Chen FE; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai, 200433, China.
Shen QK; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China. Electronic address: qkshen@ybu.edu.cn.
Quan ZS; Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China. Electronic address: zsquan@ybu.edu.cn.

Eur J Med Chem ; 259: 115697, 2023 Nov 05.

Article em En | MEDLINE | ID: mdl-37544187

Assuntos

Lesão Pulmonar Aguda; NF-kappa B; Animais; Camundongos; NF-kappa B/metabolismo; Ácido Fusídico; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Interleucina-6/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Inflamassomos/metabolismo; Lipopolissacarídeos/farmacologia; Ciclo-Oxigenase 2/metabolismo; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Lesão Pulmonar Aguda/induzido quimicamente; Lesão Pulmonar Aguda/tratamento farmacológico; Óxido Nítrico Sintase Tipo II/metabolismo; Óxido Nítrico/metabolismo

Palavras-chave

Anti-inflammatory; Fusidic acid; MAPK/NF-κB/NLRP3 inflammasome; Structure-activity relationships; Synthesis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: NF-kappa B / Lesão Pulmonar Aguda Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google