Application of fused-grid-based CYP-Template systems for genotoxic substances to understand the metabolisms.

Yamazoe, Yasushi; Murayama, Norie; Kawamura, Tomoko; Yamada, Takashi

Yamazoe, Yasushi; Murayama, Norie; Kawamura, Tomoko; Yamada, Takashi.

Afiliação

Yamazoe Y; Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-ku, Sendai, 980-8578, Japan. yasushi.yamazoe.a4@tohoku.ac.jp.
Murayama N; Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan. yasushi.yamazoe.a4@tohoku.ac.jp.
Kawamura T; Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Yamada T; Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan.

Genes Environ ; 45(1): 22, 2023 Aug 07.

Article em En | MEDLINE | ID: mdl-37544994

Palavras-chave

CYP-mediated activation; Co-mutagenicity; Distinction between human and rodent CYP1A1; Enhancement and simultaneous bi-molecule sittings; Fused hexagonal-grid Template system; P450 induction; Regioselectivity and placement on Template

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Genes Environ Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Genes Environ Ano de publicação: 2023 Tipo de documento: Article