Your browser doesn't support javascript.
loading
Diabetes and incidence of breast cancer and its molecular subtypes: A systematic review and meta-analysis.
Xiong, Fanxiu; Dai, Qichen; Zhang, Sihan; Bent, Stephen; Tahir, Peggy; Van Blarigan, Erin L; Kenfield, Stacey A; Chan, June M; Schmajuk, Gabriela; Graff, Rebecca E.
Afiliação
  • Xiong F; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Dai Q; Department of Breast Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Zhang S; Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Bent S; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Tahir P; Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA.
  • Van Blarigan EL; UCSF Library, University of California, San Francisco, San Francisco, California, USA.
  • Kenfield SA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Chan JM; Department of Urology, University of California, San Francisco, San Francisco, California, USA.
  • Schmajuk G; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Graff RE; Department of Urology, University of California, San Francisco, San Francisco, California, USA.
Diabetes Metab Res Rev ; 40(1): e3709, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37545374
ABSTRACT
Diabetes mellitus (DM) has been proposed to be positively associated with breast cancer (BCa) risk due to shared risk factors, metabolic dysfunction, and the use of antidiabetic medications. We conducted a systematic review and meta-analysis to evaluate the association between DM and BCa risk. We searched PubMed, Embase, and Web of Science for cohort and case-control studies assessing the association between DM and BCa published before 10 December 2021. Two reviewers independently screened the studies for inclusion, abstracted article data, and rated study quality. Random effects models were used to estimate summary risk ratios (RRs) and 95% confidence intervals (CIs). From 8396 articles identified in the initial search, 70 independent studies were included in the meta-analysis. DM was associated with an overall increased risk of BCa (RR = 1.20, 95% CI 1.11-1.29). The 24 case-control studies demonstrated a stronger association (RR = 1.26, 95% CI 1.13-1.40) than the 46 cohort studies (RR = 1.15, 95% CI 1.05-1.27). Studies reporting risk by menopausal status found that postmenopausal women had an elevated risk of developing BCa (RR = 1.12, 95% CI 1.07-1.17). No association between DM and BCa risk was observed among premenopausal women (RR = 0.95, 95% CI 0.85-1.05). In addition, DM was associated with significantly increased risks of oestrogen receptor (ER)+ (RR = 1.09, 95% CI 1.00-1.20), ER- (RR = 1.16, 95% CI 1.04-1.30), and triple negative BCa (RR = 1.41, 95% CI 1.01-1.96). The association estimate for human epidermal growth factor 2-positive BCa was also positive (RR = 1.21, 95% CI 0.52-2.82), but the CI was wide and crossed the null. Our meta-analysis confirms a modest positive association between DM and BCa risk. In addition, our results suggest that the association between DM and BCa may be modified by menopausal status, and that DM may be differentially associated with BCa subtypes defined by receptor status. Additional studies are warranted to investigate the mechanisms underlying these associations and any influence of DM on BCa receptor expression.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Diabetes Mellitus Tipo 2 Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans Idioma: En Revista: Diabetes Metab Res Rev Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Diabetes Mellitus Tipo 2 Tipo de estudo: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Female / Humans Idioma: En Revista: Diabetes Metab Res Rev Ano de publicação: 2024 Tipo de documento: Article