Heterochronic Plasma Transfer: Experimental Design, Considerations, and Technical Challenges.
Rejuvenation Res
; 26(5): 171-179, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37551981
ABSTRACT
Experimental approaches such as Heterochronic Plasma Transfer (HPT) provide insights into the aging process and help identify the factors that impact aging, with the aim of developing anti-aging therapies. HPT involves the transfer of plasma from an animal of one age to an animal of a different age and highlights the effects of the systemic environment on aging. Despite its importance as an aging research tool, HPT is not without limitations and HPT experiments across various studies differ in key experimental designs considerations, presenting a challenge in obtaining comparable outcomes. In this review, we examine the caveats and experimental design considerations of HPT as a research tool. We provide insights into plasma preparation procedures, route of administration, dosing regimen, and appropriate controls to assist investigators in achieving their experimental goals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parabiose
/
Projetos de Pesquisa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Rejuvenation Res
Ano de publicação:
2023
Tipo de documento:
Article