Urolithin B inhibits proliferation and migration and promotes apoptosis and necrosis by inducing G2/M arrest and targeting MMP-2/-9 expression in osteosarcoma cells.

Tajvar Nasab, Nahid; Jalili-Nik, Mohammad; Afshari, Amir R; Rezaei Farimani, Azam; Soukhtanloo, Mohammad

Tajvar Nasab, Nahid; Jalili-Nik, Mohammad; Afshari, Amir R; Rezaei Farimani, Azam; Soukhtanloo, Mohammad.

Afiliação

Tajvar Nasab N; Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Jalili-Nik M; Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Afshari AR; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Rezaei Farimani A; Department of Physiology and Pharmacology, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Soukhtanloo M; Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

J Biochem Mol Toxicol ; 37(12): e23486, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37555500

Assuntos

Apoptose; Osteossarcoma; Humanos; Proteína Supressora de Tumor p53; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 2 da Matriz/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Proteína X Associada a bcl-2/metabolismo; Pontos de Checagem da Fase G2 do Ciclo Celular; Linhagem Celular Tumoral; Necrose; Proliferação de Células; Osteossarcoma/metabolismo; RNA Mensageiro; Movimento Celular

Palavras-chave

apoptosis; metastasis; migration; osteosarcoma; urolithin B

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteossarcoma / Apoptose Limite: Humans Idioma: En Revista: J Biochem Mol Toxicol Ano de publicação: 2023 Tipo de documento: Article

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