Finding Needles in the Haystack: Strategies for Uncovering Noncoding Regulatory Variants.
Annu Rev Genet
; 57: 201-222, 2023 11 27.
Article
em En
| MEDLINE
| ID: mdl-37562413
ABSTRACT
Despite accumulating evidence implicating noncoding variants in human diseases, unraveling their functionality remains a significant challenge. Systematic annotations of the regulatory landscape and the growth of sequence variant data sets have fueled the development of tools and methods to identify causal noncoding variants and evaluate their regulatory effects. Here, we review the latest advances in the field and discuss potential future research avenues to gain a more in-depth understanding of noncoding regulatory variants.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Predisposição Genética para Doença
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Genet
Ano de publicação:
2023
Tipo de documento:
Article