Reduction in postoperative sore throat by preoperative nebulization with dexmedetomidine, ketamine or saline: A prospective, randomized-controlled trial.
J Anaesthesiol Clin Pharmacol
; 39(2): 201-207, 2023.
Article
em En
| MEDLINE
| ID: mdl-37564855
ABSTRACT
Background and Aims:
Postoperative sore throat (POST) is a minor but distressing complication following general anesthesia. The current literature on the effect of preoperative nebulization with dexmedetomidine, or ketamine on POST is, however, sparse. So, we compared the effect of preoperative nebulization with these drugs on POST. Material andMethods:
One hundred and thirty-two American Society of Anaesthesiology (ASA) grade I-II patients undergoing elective laparoscopic surgeries under general anesthesia were randomized into three equal groups D, K, or C to receive dexmedetomidine, ketamine, or saline as preoperative nebulization, respectively. The primary objective was to compare the incidence and severity of POST, as inferred from the patient interviews at 2, 6, 12, 24-h postoperatively.Results:
Group D had a significantly lower incidence (29.5%) and severity (12 mild; 1 moderate) of POST compared to group K (54.5% [21 mild; 3 moderate]) and group C (56.8% [19 mild; 6 moderate]), at 2-h postoperatively. The same trend was observed at 6-h postoperatively (group D 22.7% [9 mild; 1 moderate]); group K (40.9% [17 mild; 1 moderate]); group C (50% [17 mild; 5 moderate]). The mean arterial pressure was significantly lower in group D at 15 min intraoperatively (84.09 mmHg, P = 0.018) and immediate postoperatively (97.60 mmHg, P = 0.034). The postoperative sedation, nausea, and vomiting was not statistically significant.Conclusion:
Preoperative nebulization with dexmedetomidine is effective in the reduction of the incidence and severity of early POST.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Idioma:
En
Revista:
J Anaesthesiol Clin Pharmacol
Ano de publicação:
2023
Tipo de documento:
Article