Mono-(2-ethylhexyl)-phthalate potentiates methylglyoxal-induced blood-brain barrier damage via mitochondria-derived oxidative stress and bioenergetic perturbation.

Kim, Donghyun; Oh, Eujin; Kim, Haram; Baek, Seung Mi; Cho, Junho; Kim, Eun-Hye; Choi, Sungbin; Bian, Yiying; Kim, Wondong; Bae, Ok-Nam

Kim, Donghyun; Oh, Eujin; Kim, Haram; Baek, Seung Mi; Cho, Junho; Kim, Eun-Hye; Choi, Sungbin; Bian, Yiying; Kim, Wondong; Bae, Ok-Nam.

Afiliação

Kim D; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Oh E; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Kim H; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Baek SM; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Cho J; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Kim EH; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Choi S; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Bian Y; School of Public Health, China Medical University, Shenyang, 110122, China.
Kim W; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea.
Bae ON; College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea. Electronic address: onbae@hanyang.ac.kr.

Food Chem Toxicol ; 179: 113985, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37572985

Assuntos

Dietilexilftalato; Ratos; Animais; Dietilexilftalato/toxicidade; Aldeído Pirúvico; Barreira Hematoencefálica/metabolismo; Células Endoteliais/metabolismo; Estresse Oxidativo; Metabolismo Energético; Mitocôndrias/metabolismo

Palavras-chave

BBB; Bloodbrain barrier; DEHP; Di-(2-ethylhexyl) phthalate; Diabetes; MEHP; MG; Methylglyoxal; Mitochondria; Mono-(2-ethylhexyl) phthalate; Phthalate; ROS; Reactive oxygen species

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dietilexilftalato Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2023 Tipo de documento: Article

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