Aryl hydrocarbon receptor: A bridge linking immuno-inflammation and metabolism in atherosclerosis.
Biochem Pharmacol
; 216: 115744, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37579858
ABSTRACT
Cardiovascular disease is the leading cause of death worldwide, and atherosclerosis is a major contributor to this etiology. The ligand-activated transcription factor, known as the aryl hydrocarbon receptor (AhR), plays an essential role in the interactions between genes and the environment. In a number of human diseases, including atherosclerosis, the AhR signaling pathway has recently been shown to be aberrantly expressed and activated. It's reported that AhR can regulate the immuno-inflammatory response and metabolism pathways in atherosclerosis, potentially serving as a bridge that links these processes. In this review, we highlight the involvement of AhR in atherosclerosis. From the literature, we conclude that AhR is a potential target for controlling atherosclerosis through precise interventions.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
2023
Tipo de documento:
Article