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Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation.
Geffen, Yifat; Anand, Shankara; Akiyama, Yo; Yaron, Tomer M; Song, Yizhe; Johnson, Jared L; Govindan, Akshay; Babur, Özgün; Li, Yize; Huntsman, Emily; Wang, Liang-Bo; Birger, Chet; Heiman, David I; Zhang, Qing; Miller, Mendy; Maruvka, Yosef E; Haradhvala, Nicholas J; Calinawan, Anna; Belkin, Saveliy; Kerelsky, Alexander; Clauser, Karl R; Krug, Karsten; Satpathy, Shankha; Payne, Samuel H; Mani, D R; Gillette, Michael A; Dhanasekaran, Saravana M; Thiagarajan, Mathangi; Mesri, Mehdi; Rodriguez, Henry; Robles, Ana I; Carr, Steven A; Lazar, Alexander J; Aguet, François; Cantley, Lewis C; Ding, Li; Getz, Gad.
Afiliação
  • Geffen Y; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02115, USA.
  • Anand S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Akiyama Y; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Yaron TM; Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA.
  • Song Y; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Johnson JL; Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA.
  • Govindan A; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Babur Ö; Department of Computer Science, University of Massachusetts Boston, Boston, MA 02125, USA.
  • Li Y; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Huntsman E; Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA.
  • Wang LB; Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Birger C; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Heiman DI; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Zhang Q; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Miller M; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Maruvka YE; Biotechnology and Food Engineering, Lokey Center for Life Science and Engineering, Technion, Israel Institute of Technology, Haifa, Israel.
  • Haradhvala NJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Calinawan A; Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Belkin S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Kerelsky A; Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA.
  • Clauser KR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Krug K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Satpathy S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Payne SH; Department of Biology, Brigham Young University, Provo, UT 84602, USA.
  • Mani DR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Gillette MA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Dhanasekaran SM; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Thiagarajan M; Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  • Mesri M; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA.
  • Rodriguez H; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA.
  • Robles AI; Office of Cancer Clinical Proteomics Research, National Cancer Institute, Rockville, MD 20850, USA.
  • Carr SA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
  • Lazar AJ; Departments of Pathology & Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Aguet F; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA. Electronic address: faguet@illumina.com.
  • Cantley LC; Weill Cornell Medical College, Meyer Cancer Center, New York, NY 10021, USA. Electronic address: lewis_cantley@dfci.harvard.edu.
  • Ding L; Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: lding@wustl.edu.
  • Getz G; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: gadgetz@broadinstitute.org.
Cell ; 186(18): 3945-3967.e26, 2023 08 31.
Article em En | MEDLINE | ID: mdl-37582358
ABSTRACT
Post-translational modifications (PTMs) play key roles in regulating cell signaling and physiology in both normal and cancer cells. Advances in mass spectrometry enable high-throughput, accurate, and sensitive measurement of PTM levels to better understand their role, prevalence, and crosstalk. Here, we analyze the largest collection of proteogenomics data from 1,110 patients with PTM profiles across 11 cancer types (10 from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium [CPTAC]). Our study reveals pan-cancer patterns of changes in protein acetylation and phosphorylation involved in hallmark cancer processes. These patterns revealed subsets of tumors, from different cancer types, including those with dysregulated DNA repair driven by phosphorylation, altered metabolic regulation associated with immune response driven by acetylation, affected kinase specificity by crosstalk between acetylation and phosphorylation, and modified histone regulation. Overall, this resource highlights the rich biology governed by PTMs and exposes potential new therapeutic avenues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteômica / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Processamento de Proteína Pós-Traducional / Proteômica / Neoplasias Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article