Yolk sac cell atlas reveals multiorgan functions during human early development.
Science
; 381(6659): eadd7564, 2023 08 18.
Article
em En
| MEDLINE
| ID: mdl-37590359
ABSTRACT
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saco Vitelino
/
Desenvolvimento Embrionário
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Science
Ano de publicação:
2023
Tipo de documento:
Article