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Yolk sac cell atlas reveals multiorgan functions during human early development.
Goh, Issac; Botting, Rachel A; Rose, Antony; Webb, Simone; Engelbert, Justin; Gitton, Yorick; Stephenson, Emily; Quiroga Londoño, Mariana; Mather, Michael; Mende, Nicole; Imaz-Rosshandler, Ivan; Yang, Lu; Horsfall, Dave; Basurto-Lozada, Daniela; Chipampe, Nana-Jane; Rook, Victoria; Lee, Jimmy Tsz Hang; Ton, Mai-Linh; Keitley, Daniel; Mazin, Pavel; Vijayabaskar, M S; Hannah, Rebecca; Gambardella, Laure; Green, Kile; Ballereau, Stephane; Inoue, Megumi; Tuck, Elizabeth; Lorenzi, Valentina; Kwakwa, Kwasi; Alsinet, Clara; Olabi, Bayanne; Miah, Mohi; Admane, Chloe; Popescu, Dorin-Mirel; Acres, Meghan; Dixon, David; Ness, Thomas; Coulthard, Rowen; Lisgo, Steven; Henderson, Deborah J; Dann, Emma; Suo, Chenqu; Kinston, Sarah J; Park, Jong-Eun; Polanski, Krzysztof; Marioni, John; van Dongen, Stijn; Meyer, Kerstin B; de Bruijn, Marella; Palis, James.
Afiliação
  • Goh I; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Rose A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Webb S; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Engelbert J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Gitton Y; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Stephenson E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Quiroga Londoño M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Mather M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Mende N; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
  • Imaz-Rosshandler I; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Yang L; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Horsfall D; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Basurto-Lozada D; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Chipampe NJ; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Rook V; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Lee JTH; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CD2 0QH, UK.
  • Ton ML; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Keitley D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Mazin P; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Vijayabaskar MS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Hannah R; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Gambardella L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Green K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Ballereau S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Inoue M; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Tuck E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Lorenzi V; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
  • Kwakwa K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Alsinet C; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Olabi B; Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.
  • Miah M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Admane C; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Popescu DM; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Acres M; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.
  • Dixon D; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Ness T; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Coulthard R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Lisgo S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Henderson DJ; Centre Nacional d'Analisi Genomica-Centre de Regulacio Genomica (CNAG-CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
  • Dann E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Suo C; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Kinston SJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Park JE; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
  • Marioni J; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • van Dongen S; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Meyer KB; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • de Bruijn M; Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
  • Palis J; NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.
Science ; 381(6659): eadd7564, 2023 08 18.
Article em En | MEDLINE | ID: mdl-37590359
ABSTRACT
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saco Vitelino / Desenvolvimento Embrionário Limite: Female / Humans / Pregnancy Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saco Vitelino / Desenvolvimento Embrionário Limite: Female / Humans / Pregnancy Idioma: En Revista: Science Ano de publicação: 2023 Tipo de documento: Article