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PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies.
Cox, Bianca; Wauters, Natasha; Rodríguez-Carrillo, Andrea; Portengen, Lützen; Gerofke, Antje; Kolossa-Gehring, Marike; Lignell, Sanna; Lindroos, Anna Karin; Fabelova, Lucia; Murinova, Lubica Palkovicova; Desalegn, Anteneh; Iszatt, Nina; Schillemans, Tessa; Åkesson, Agneta; Colles, Ann; Den Hond, Elly; Koppen, Gudrun; Van Larebeke, Nicolas; Schoeters, Greet; Govarts, Eva; Remy, Sylvie.
Afiliação
  • Cox B; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Wauters N; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Rodríguez-Carrillo A; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Portengen L; Toxicological Centre, University of Antwerp, Universiteitsplein, 1, 2610 Wilrijk, Belgium.
  • Gerofke A; Institute for Risk Assessment Sciences, Utrecht University, 3584 Utrecht, The Netherlands.
  • Kolossa-Gehring M; German Environment Agency, Umweltbundesamt (UBA), 14195 Berlin, Germany.
  • Lignell S; German Environment Agency, Umweltbundesamt (UBA), 14195 Berlin, Germany.
  • Lindroos AK; Swedish Food Agency, 751 26 Uppsala, Sweden.
  • Fabelova L; Swedish Food Agency, 751 26 Uppsala, Sweden.
  • Murinova LP; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, 831 01 Bratislava, Slovakia.
  • Desalegn A; Department of Environmental Medicine, Faculty of Public Health, Slovak Medical University, 831 01 Bratislava, Slovakia.
  • Iszatt N; Division of Climate and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway.
  • Schillemans T; Division of Climate and Environmental Health, Norwegian Institute of Public Health, 0456 Oslo, Norway.
  • Åkesson A; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Colles A; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Den Hond E; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Koppen G; Provincial Institute of Hygiene, Provincial Research Centre for Environment and Health, 2023 Antwerp, Belgium.
  • Van Larebeke N; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Schoeters G; Analytical, Environmental and Geo-Chemistry, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Govarts E; VITO Health, Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
  • Remy S; Department of Biomedical Sciences, University of Antwerp, 2000 Antwerp, Belgium.
Toxics ; 11(8)2023 Aug 18.
Article em En | MEDLINE | ID: mdl-37624216
Early puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases and hormone-dependent cancers. The decrease in age at menarche observed during the past decades has been linked to an increased exposure to endocrine-disrupting compounds (EDCs). Evidence for the association between PFAS and phthalate exposure and menarche onset, however, is inconsistent. We studied the association between PFAS and phthalate/DINCH exposure and age at menarche using data of 514 teenagers (12 to 18 years) from four aligned studies of the Human Biomonitoring for Europe initiative (HBM4EU): Riksmaten Adolescents 2016-2017 (Sweden), PCB cohort (follow-up; Slovakia), GerES V-sub (Germany), and FLEHS IV (Belgium). PFAS concentrations were measured in blood, and phthalate/DINCH concentrations in urine. We assessed the role of each individual pollutant within the context of the others, by using different multi-pollutant approaches, adjusting for age, age- and sex-standardized body mass index z-score and household educational level. Exposure to di(2-ethylhexyl) phthalate (DEHP), especially mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), was associated with an earlier age at menarche, with estimates per interquartile fold change in 5OH-MEHP ranging from -0.34 to -0.12 years in the different models. Findings from this study indicated associations between age at menarche and some specific EDCs at concentrations detected in the general European population, but due to the study design (menarche onset preceded the chemical measurements), caution is needed in the interpretation of causality.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Toxics Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Toxics Ano de publicação: 2023 Tipo de documento: Article