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Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia.
Ghanem-Zoubi, Nesrin; Abu-Elhija, Jawad; Kagna, Olga; Mustafa-Hellou, Mona; Qasum, Majd; Haber, Daniel; Paul, Mical; Keidar, Zohar.
Afiliação
  • Ghanem-Zoubi N; Infectious Diseases Institute, Rambam Health Care Campus, Ha-Aliya 8 St, 3109601, Haifa, Israel. n_ghanem@rambam.health.gov.il.
  • Abu-Elhija J; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel. n_ghanem@rambam.health.gov.il.
  • Kagna O; Internal Medicine Department E, Rambam Health Care Campus, Haifa, Israel.
  • Mustafa-Hellou M; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
  • Qasum M; Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel.
  • Haber D; Infectious Diseases Institute, Rambam Health Care Campus, Ha-Aliya 8 St, 3109601, Haifa, Israel.
  • Paul M; Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel.
  • Keidar Z; Department of Cardiology, Rambam Health Care Campus, Haifa, Israel.
Sci Rep ; 13(1): 14063, 2023 08 28.
Article em En | MEDLINE | ID: mdl-37640802
ABSTRACT
We looked for predicting factors for the detection of infectious foci on 18F-fluorodeoxyglucose-positron emission tomography in combination with computed tomography (FDG PET/CT) among patients with Staphylococcus aureus bacteremia (SAB) who participated in an interventional study that was conducted at Rambam Health Care Campus, between July 1, 2015 and February 1, 2019. The primary outcome was an infectious focus detected by FDG PET/CT. Independent predictors for detection of focal infection were identified using univariate followed by a logistic regression multivariate analysis. We included 149 patients with 151 separate episodes of SAB who underwent FDG-PET/CT. Focal infections were detected in 107 patients (70.8%). Independent predictors for focal infection detection were community acquisition of bacteremia with odds ratio (OR) 3.03 [95% confidence interval (CI) 1.04-8.77], p-0.042 and C reactive protein (CRP) with OR 1.09 [95% CI 1.04-1.14], p < 0.001. Primary bacteremia was inversely associated with focal infection detection with OR 0.27 [0.10-0.69], p = 0.007, as were the pre-scan blood glucose levels OR 0.9 [0.98-0.99], p-0.004. The latter stayed significant in the subgroup of patients with diabetes mellitus. To conclude, patients with community-acquired bacteremia or high CRP levels should be carefully investigated for focal infection. Patients who present with primary bacteremia seem to be at low risk for focal infection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Doenças Transmissíveis / Bacteriemia / Infecção Focal Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estafilocócicas / Doenças Transmissíveis / Bacteriemia / Infecção Focal Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2023 Tipo de documento: Article