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An orexigenic subnetwork within the human hippocampus.
Barbosa, Daniel A N; Gattas, Sandra; Salgado, Juliana S; Kuijper, Fiene Marie; Wang, Allan R; Huang, Yuhao; Kakusa, Bina; Leuze, Christoph; Luczak, Artur; Rapp, Paul; Malenka, Robert C; Hermes, Dora; Miller, Kai J; Heifets, Boris D; Bohon, Cara; McNab, Jennifer A; Halpern, Casey H.
Afiliação
  • Barbosa DAN; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Gattas S; Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, CA, USA.
  • Salgado JS; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Kuijper FM; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Wang AR; Université Paris Cité, Paris, France.
  • Huang Y; Assistance Publique des Hôpitaux de Paris, Paris, France.
  • Kakusa B; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Leuze C; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Luczak A; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
  • Rapp P; Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
  • Malenka RC; Canadian Centre for Behavioral Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
  • Hermes D; Department of Military & Emergency Medicine, Uniformed Services University, Bethesda, MD, USA.
  • Miller KJ; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Heifets BD; Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Bohon C; Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • McNab JA; Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
  • Halpern CH; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Nature ; 621(7978): 381-388, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37648849
Only recently have more specific circuit-probing techniques become available to inform previous reports implicating the rodent hippocampus in orexigenic appetitive processing1-4. This function has been reported to be mediated at least in part by lateral hypothalamic inputs, including those involving orexigenic lateral hypothalamic neuropeptides, such as melanin-concentrating hormone5,6. This circuit, however, remains elusive in humans. Here we combine tractography, intracranial electrophysiology, cortico-subcortical evoked potentials, and brain-clearing 3D histology to identify an orexigenic circuit involving the lateral hypothalamus and converging in a hippocampal subregion. We found that low-frequency power is modulated by sweet-fat food cues, and this modulation was specific to the dorsolateral hippocampus. Structural and functional analyses of this circuit in a human cohort exhibiting dysregulated eating behaviour revealed connectivity that was inversely related to body mass index. Collectively, this multimodal approach describes an orexigenic subnetwork within the human hippocampus implicated in obesity and related eating disorders.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orexinas / Hipocampo / Vias Neurais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Orexinas / Hipocampo / Vias Neurais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article