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Paternal and maternal birthweight and offspring risk of macrosomia at term gestations: A nationwide population study.
Rasmussen, Svein; Carlsen, Ellen Øen; Linde, Lorentz Erland; Morken, Nils-Halvdan; Håberg, Siri Eldevik; Ebbing, Cathrine.
Afiliação
  • Rasmussen S; Department of Clinical Science, Maternal-Fetal-Neonatal Research, University of Bergen, Bergen, Norway.
  • Carlsen EØ; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Linde LE; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
  • Morken NH; Department of Clinical Science, Maternal-Fetal-Neonatal Research, University of Bergen, Bergen, Norway.
  • Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
  • Ebbing C; Department of Clinical Science, Maternal-Fetal-Neonatal Research, University of Bergen, Bergen, Norway.
Paediatr Perinat Epidemiol ; 38(3): 183-192, 2024 Mar.
Article em En | MEDLINE | ID: mdl-37658778
BACKGROUND: There is a paucity of data on whether parents' macrosomia (birthweight ≥4500 g) status influences the risk of macrosomia in the offspring. The role of maternal overweight in the generational effect of macrosomia is not known. OBJECTIVE: To estimate the risk of macrosomia by parental birthweight at term and evaluate if this risk varied with maternal body mass index (BMI, kg/m2) early in pregnancy. METHODS: We used data from the Medical Birth Registry of Norway on all singleton term births (37-42 gestational weeks) during 1967-2017. The primary exposure was parental macrosomia, and the outcome was macrosomia in the second generation. The secondary exposure was maternal BMI. We used binomial regression to calculate relative risk (RR) with a 95% confidence interval. We assessed potential unmeasured confounding and selection bias using a probabilistic bias analysis and performed analyses with and without imputation for variables with missing values. RESULTS: The data included 647,957 singleton parent-offspring trios born at term. The prevalence of macrosomia was 3.2% (n = 41,396) in the parental generation and 4.0% (n = 25,673) in the offspring generation. Macrosomia in parents was associated with an increased risk of macrosomia in offspring, with the RR for both parents were born macrosomic being 6.53 (95% confidence interval [CI] 5.31, 8.05), only mother macrosomic 3.37 (95% CI 3.17, 3.57) and only father macrosomic RR 2.22 (95% CI 2.12, 2.33). These risks increased by maternal BMI in early pregnancy: if both parents were born macrosomic, 17% of infants were macrosomic among mothers with normal BMI. If both parents were macrosomic and the mothers were obese, 31% of offspring were macrosomic. Macrosomia-related adverse outcomes did not differ with parental macrosomia status. CONCLUSIONS: Parents' weight at birth and maternal BMI appear to be strongly associated with macrosomia in the offspring delivered at term gestations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Macrossomia Fetal / Obesidade Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: Paediatr Perinat Epidemiol Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Macrossomia Fetal / Obesidade Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn / Pregnancy Idioma: En Revista: Paediatr Perinat Epidemiol Ano de publicação: 2024 Tipo de documento: Article