Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells.

Manandhar, Sumeet; Chambers, Stephen; Miller, Andrew; Ishii, Isao; Bhatia, Madhav

Manandhar, Sumeet; Chambers, Stephen; Miller, Andrew; Ishii, Isao; Bhatia, Madhav.

Afiliação

Manandhar S; Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Chambers S; Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Miller A; Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Ishii I; Department of Health Chemistry, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.
Bhatia M; Department of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.

Int J Mol Sci ; 24(17)2023 Sep 04.

Article em En | MEDLINE | ID: mdl-37686458

Assuntos

Cistationina gama-Liase; Sepse; Animais; Camundongos; Moléculas de Adesão Celular; Cistationina gama-Liase/antagonistas & inibidores; Cistationina gama-Liase/genética; Células Endoteliais; Deleção de Genes; NF-kappa B; Sepse/tratamento farmacológico; Sepse/genética

Palavras-chave

adhesion molecules; cystathionine gamma-lyase; endothelial cells; hydrogen sulfide; sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Cistationina gama-Liase Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article

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