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Comparison of miRNA transcriptome of exosomes in three categories of somatic cells with derived iPSCs.
Yu, Chunlai; Zhang, Mei; Xiong, Yucui; Wang, Qizheng; Wang, Yuanhua; Wu, Shaoling; Hussain, Sajjad; Wang, Yan; Zhang, Zhizhong; Rao, Nini; Zhang, Sheng; Zhang, Xiao.
Afiliação
  • Yu C; University of Electronic Science and Technology of China, Chengdu, Sichuang, China.
  • Zhang M; Binzhou Medical University, Yantai, Shandong, China.
  • Xiong Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Wang Q; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Wang Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Wu S; Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Hussain S; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Wang Y; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang Z; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Rao N; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
  • Zhang S; University of Electronic Science and Technology of China, Chengdu, Sichuang, China. raonn@uestc.edu.cn.
  • Zhang X; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China. zhang_sheng@gibh.ac.cn.
Sci Data ; 10(1): 616, 2023 09 11.
Article em En | MEDLINE | ID: mdl-37696871
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through epigenetic manipulation. While the essential role of miRNA in reprogramming and maintaining pluripotency is well studied, little is known about the functions of miRNA from exosomes in this context. To fill this research gap,we comprehensively obtained the 17 sets of cellular mRNA transcriptomic data with 3.93 × 1010 bp raw reads and 18 sets of exosomal miRNA transcriptomic data with 2.83 × 107 bp raw reads from three categories of human somatic cells: peripheral blood mononuclear cells (PBMCs), skin fibroblasts(SFs) and urine cells (UCs), along with their derived iPSCs. Additionally, differentially expressed molecules of each category were identified and used to perform gene set enrichment analysis. Our study provides sets of comparative transcriptomic data of cellular mRNA and exosomal miRNA from three categories of human tissue with three individual biological controls in studies of iPSCs generation, which will contribute to a better understanding of donor cell variation in functional epigenetic regulation and differentiation bias in iPSCs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2023 Tipo de documento: Article