Early Organic Chemistry in Kyiv: Serhii Mykolayovych Reformatskyi (1860-1934) and his Name Reaction.
Chempluschem
; 88(10): e202300224, 2023 Oct.
Article
em En
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| ID: mdl-37702126
ABSTRACT
Serhiy Mykolayovych Reformatskyi, [Ukrainian Ð eφopмaÑcÑκий, Cepгiй MиκoлaйoвиÑ; Russian Sergei Nikolaevich Reformatskii, Ð eΦopмaÑcκий, Cepгeй HиκoлaeÐ²Ð¸Ñ (1860-1934)] was a product of Zaitsev's laboratory in Kazan Imperial University in Russia and one of the founding fathers of organic chemistry in Ukraine. He discovered his eponymous reaction while a graduate student in Kazan under Zaitsev, studying the synthesis of homoallylic alcohols. He modified this reaction by replacing the olefinic π bond of an allyl halide with a carbonyl group. In the prototype reaction, he treated ethyl haloacetates with zinc and aldehydes or ketones. The reaction gave the corresponding ß-hydroxyesters and remains an important synthetic method. Work on the reaction over the ensuing century and a quarter has led to the discovery of analogous reactions using a wide range of metals, and even permitting the use of water as a solvent.
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Chempluschem
Ano de publicação:
2023
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Article