Plant-derived cell-penetrating microprotein &#945;-astratide aM1 targets Akt signaling and alleviates insulin resistance.

Dutta, Bamaprasad; Loo, Shining; Kam, Antony; Tam, James P

Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance.

Dutta, Bamaprasad; Loo, Shining; Kam, Antony; Tam, James P.

Afiliação

Dutta B; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.
Loo S; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.
Kam A; Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.
Tam JP; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore, 637551, Singapore.

Cell Mol Life Sci ; 80(10): 293, 2023 Sep 16.

Article em En | MEDLINE | ID: mdl-37715850

Assuntos

Resistência à Insulina; Humanos; Proteínas Proto-Oncogênicas c-akt; Fosfatidilinositol 3-Quinases; Insulina/farmacologia; Transdução de Sinais; Glucose; Lipídeos; Micropeptídeos

Palavras-chave

Cell penetration; Cholesterol biosynthesis; Diabetes; Glucose uptake; IRS1/2; Insulin resistance; Insulin-mimetic; Leginsulin; Microproteins; PI3K/Akt signaling; PKCÎ¸; α-Astratide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Ano de publicação: 2023 Tipo de documento: Article

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