Prognostic Value of the Average Lung CT Number in Patients with Acute Paraquat Poisoning.

ABSTRACT

Objective: The chest computed tomography (CT) examination is an important clinical examination in the diagnosis and monitoring of paraquat- (PQ-) induced lung injury. The aim of this study was to explore the prognostic value of the average lung CT number acquired by quantitative CT techniques in patients with acute paraquat poisoning in the early stages of the disease. Methods: 46 patients who suffered from acute PQ poisoning in the emergency department of the Nanjing Drum Tower Hospital from January 2015 to June 2020 were enrolled in the present study. The patients were divided into survival group (n = 21) and nonsurvival group (n = 25). Clinical data were collected from subjects who met the inclusion criteria, including general information, personal disease history, and laboratory test indicators. The average lung CT numbers of each patient were obtained by quantitative CT techniques. Receiver operating characteristic (ROC) analysis was conducted to assess the prognostic value of average lung CT number in patients with acute paraquat poisoning. Results: The average CT numbers of the middle-lung, lower-lung, and whole lung fields in the nonsurvival group were significantly higher than those of the survival group (p < 0.0001). However, the upper-lung field was not significantly different between the two groups (p = 0.7765). The AUCs of different levels ranged from 0.554 to 0.977, among which the lower-lung field presented the largest AUC of 0.977 (95% CI 0.943∼1; cut-off value -702Hu; sensitivity 96%; specificity, 90.5%; YI 0.865), followed by the whole lung field 0.914 (95% CI 0.830∼0.999; cut-off value -727Hu; sensitivity 76%; specificity, 95.2%; YI 0.712) and the middle-lung field 0.87 (95% CI 0.768∼0.971; cut-off value -779Hu; sensitivity 80%; specificity, 85.7%; YI 0.657). Conclusion: The present study indicated that the average lung CT number could be used to evaluate the relationship between the severity of PQ-induced lung injury and prognosis, especially in the lower-lung field. However, further research is needed to draw a clear conclusion.