In Vitro Characterization of Drug-Loaded Superabsorbent Polymer Microspheres: Absorption and Release Capacity of Contrast Material, Antibiotics and Analgesics.
Cardiovasc Intervent Radiol
; 46(11): 1632-1640, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37759091
ABSTRACT
PURPOSE:
To examine the characteristics of drug-loaded superabsorbent polymer microspheres (SAP-MS) such as drug absorption, drug release, diameter, and visibility. MATERIALS ANDMETHODS:
SAP-MS (HepaSphere150-200 µm; Merit Medical, South Jordan, UT, USA) were suspended in drug solutions (a) cefazolin, (b) lidocaine, (c) iopamidol and cefazolin, (d) iopamidol and lidocaine, and (e) iopamidol, cefazolin, and lidocaine. The concentrations of drugs were measured, and the amount of each drug absorbed was calculated. Filtered drug-loaded SAP-MS were mixed with saline, and the drug release rates were calculated. The diameter changes of SAP-MS during absorption were observed. Radiography of drug-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio (CNR).RESULTS:
The drug concentration did not change during absorption. The release rates increased for 10 min and then came to an equilibrium. The mean amounts of drug absorbed at 180 min and mean release rates at 24 h were (a) cefazolin 265.4 mg, 64.2%; (b) lidocaine 19.6 mg, 75.6%; (c) iopamidol 830.2 mg, 22.5%; cefazolin 137.6 mg, 21.2%; (d) iopamidol 1620.6 mg, 78.5%; lidocaine 13.5 mg, 81.4%; and (e) iopamidol 643.7 mg, 52.9%; cefazolin 194.0 mg, 51.6%; lidocaine 5.3 mg, 58.4%. The diameter of SAP-MS increased for approximately 15 min. Finally, the diameters of SAP-MS were (a) 3.9 times, (b) 5.0 times, (c) 2.2 times, (d) 5.5 times, and (e) 3.6 times larger than the original size. Drug-loaded SAP-MS containing iopamidol were visible under X-ray imaging, with CNRs of (c) 3.0, (d) 9.0, and (e) 4.5.CONCLUSION:
SAP-MS can absorb and release iopamidol, cefazolin, and lidocaine.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meios de Contraste
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Cardiovasc Intervent Radiol
Ano de publicação:
2023
Tipo de documento:
Article