Alcohol Consumption and Antihypertensive Treatment Effect in Male Patients With Hypertension.
Am J Hypertens
; 37(2): 112-119, 2024 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-37769181
ABSTRACT
BACKGROUND:
Alcohol consumption is a proven risk factor of hypertension. In the present analysis, we investigated the use of antihypertensive medications and blood pressure control in male alcohol drinkers and non-drinkers with hypertension (systolic/diastolic blood pressure 160-199/100-119 mm Hg).METHODS:
The study participants were patients enrolled in a 12-week therapeutic study and treated with the irbesartan/hydrochlorothiazide combination 150/12.5 mg once daily, with the possible up-titration to 300/12.5 mg/day and 300/25 mg/day at 4 and 8 weeks of follow-up, respectively, for blood pressure control of <140/90 mm Hg or <130/80 mm Hg in patients with diabetes mellitus. Alcohol consumption was classified as non-drinkers and drinkers.RESULTS:
The 68 alcohol drinkers and 168 non-drinkers had similar systolic/diastolic blood pressure at baseline (160.8â ±â 12.1/99.8â ±â 8.6 vs. 161.8â ±â 11.0/99.2â ±â 8.6, Pâ ≥â 0.55) and other characteristics except for current smoking (80.9% vs. 47.6%, Pâ <â 0.0001). In patients who completed the 12-week follow-up (nâ =â 215), the use of higher dosages of antihypertensive drugs was similar at 4 weeks of follow-up in drinkers and non-drinkers (10.6% vs. 12.4%, Pâ =â 0.70), but increased to a significantly higher proportion in drinkers than non-drinkers at 12 weeks of follow-up (54.7% vs. 36.6%, Pâ =â 0.01). The control rate of hypertension tended to be lower in alcohol drinkers, compared with non-drinkers, at 4 weeks of follow-up (45.6% vs. 58.9%, Pâ =â 0.06), but became similar at 12 weeks of follow-up (51.5% vs. 54.8%, Pâ =â 0.65).CONCLUSION:
Alcohol drinkers compared with non-drinkers required a higher dosage of antihypertensive drug treatment to achieve similar blood pressure control. CLINICAL TRIAL REGISTRY NUMBER NCT00670566 at www.clinicaltrials.gov.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
/
Hipertensão
/
Anti-Hipertensivos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
En
Revista:
Am J Hypertens
Ano de publicação:
2024
Tipo de documento:
Article