Computational remodeling of an enzyme conformational landscape for altered substrate selectivity.

St-Jacques, Antony D; Rodriguez, Joshua M; Eason, Matthew G; Foster, Scott M; Khan, Safwat T; Damry, Adam M; Goto, Natalie K; Thompson, Michael C; Chica, Roberto A

St-Jacques, Antony D; Rodriguez, Joshua M; Eason, Matthew G; Foster, Scott M; Khan, Safwat T; Damry, Adam M; Goto, Natalie K; Thompson, Michael C; Chica, Roberto A.

Afiliação

St-Jacques AD; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Rodriguez JM; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Eason MG; Department of Chemistry and Biochemistry, University of California, Merced, Merced, CA, 95343, USA.
Foster SM; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Khan ST; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Damry AM; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Goto NK; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Thompson MC; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Chica RA; Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.

Nat Commun ; 14(1): 6058, 2023 09 28.

Article em En | MEDLINE | ID: mdl-37770431

Assuntos

Conformação Proteica; Domínio Catalítico; Cristalografia por Raios X

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Conformação Proteica Idioma: En Revista: Nat Commun Ano de publicação: 2023 Tipo de documento: Article

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