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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Abskharon, Romany; Pan, Hope; Sawaya, Michael R; Seidler, Paul M; Olivares, Eileen J; Chen, Yu; Murray, Kevin A; Zhang, Jeffrey; Lantz, Carter; Bentzel, Megan; Boyer, David R; Cascio, Duilio; Nguyen, Binh A; Hou, Ke; Cheng, Xinyi; Pardon, Els; Williams, Christopher K; Nana, Alissa L; Vinters, Harry V; Spina, Salvatore; Grinberg, Lea T; Seeley, William W; Steyaert, Jan; Glabe, Charles G; Ogorzalek Loo, Rachel R; Loo, Joseph A; Eisenberg, David S.
Afiliação
  • Abskharon R; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Pan H; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Sawaya MR; HHMI, UCLA, Los Angeles, CA 90095.
  • Seidler PM; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
  • Olivares EJ; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Chen Y; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Murray KA; HHMI, UCLA, Los Angeles, CA 90095.
  • Zhang J; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
  • Lantz C; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Bentzel M; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Boyer DR; HHMI, UCLA, Los Angeles, CA 90095.
  • Cascio D; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
  • Nguyen BA; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Hou K; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Cheng X; HHMI, UCLA, Los Angeles, CA 90095.
  • Pardon E; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
  • Williams CK; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Nana AL; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Vinters HV; Molecular Instrumentation Center, UCLA, Los Angeles, CA 90095.
  • Spina S; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Grinberg LT; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Seeley WW; HHMI, UCLA, Los Angeles, CA 90095.
  • Steyaert J; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
  • Glabe CG; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA 90095.
  • Ogorzalek Loo RR; Department of Biological Chemistry, UCLA, Los Angeles, CA 90095.
  • Loo JA; HHMI, UCLA, Los Angeles, CA 90095.
  • Eisenberg DS; UCLA-Department of Energy Institute, Molecular Biology Institute, UCLA, Los Angeles, CA 90095.
Proc Natl Acad Sci U S A ; 120(41): e2300258120, 2023 10 10.
Article em En | MEDLINE | ID: mdl-37801475
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paralisia Supranuclear Progressiva / Doença de Alzheimer / Anticorpos de Domínio Único Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paralisia Supranuclear Progressiva / Doença de Alzheimer / Anticorpos de Domínio Único Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article