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Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers.
McLoughlin, Eavan C; Twamley, Brendan; O'Brien, John E; Hannon Barroeta, Patricia; Zisterer, Daniela M; Meegan, Mary J; O'Boyle, Niamh M.
Afiliação
  • McLoughlin EC; School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Panoz Institute and Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2, Ireland. Electronic address: mclougea@tcd.ie.
  • Twamley B; School of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
  • O'Brien JE; School of Chemistry, Trinity College Dublin, Dublin 2, Ireland.
  • Hannon Barroeta P; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2, Ireland.
  • Zisterer DM; School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2, Ireland.
  • Meegan MJ; School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Panoz Institute and Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2, Ireland.
  • O'Boyle NM; School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Panoz Institute and Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Dublin 2, Ireland.
Bioorg Chem ; 141: 106877, 2023 12.
Article em En | MEDLINE | ID: mdl-37804699
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias de Mama Triplo Negativas Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias de Mama Triplo Negativas Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article