The possibilities of LOXL4 as a prognostic marker for carcinomas.
Amino Acids
; 55(11): 1519-1529, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37814029
ABSTRACT
Lysyl oxidase-like 4 (LOXL4), a member of lysyl oxidase family, is a copper and lysine tyrosylquinone-dependent amine oxidase that serves the role of catalyzing the cross-linking of elastin and collagen in the extracellular matrix. Numerous studies have shown a significant association between LOXL4 expression levels and tumor proliferation, migration, invasion and patients' prognosis and overall survival in different types of tumors. Here we review their relationship and the molecular pathogenesis behind them, aiming to explore the possibilities of LOXL4 as a prognostic marker for diverse carcinomas and provide some indications for further research in this field.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Proteína-Lisina 6-Oxidase
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Amino Acids
Ano de publicação:
2023
Tipo de documento:
Article