Huperzine alkaloids: forty years of total syntheses.
Nat Prod Rep
; 41(1): 59-84, 2024 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-37818549
ABSTRACT
Covering up to 2023Huperzine alkaloids are a group of natural products belonging to the Lycopodium alkaloids family. The representative member huperzine A has a unique structure and exhibits potent inhibitory activity against acetylcholine esterase (AChE). This subfamily of alkaloids provides a great opportunity for developing synthetic methodologies and asymmetric synthesis. The efforts towards the synthesis of huperzine A have cultivated dozens of total syntheses and a rich body of new chemistry. Impressive progress has also been made in the synthesis of other huperzine alkaloids. The total syntheses of huperzines B, U, O, Q and R, structure reassignment and total syntheses of huperzines K, M and N have been reported in the past decade. This review focuses on the synthetic organic chemistry and the biosynthesis and medicinal chemistry of huperzines are also covered briefly.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Lycopodium
/
Alcaloides
Idioma:
En
Revista:
Nat Prod Rep
Ano de publicação:
2024
Tipo de documento:
Article