Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues.
Chem Commun (Camb)
; 59(86): 12883-12886, 2023 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-37818645
We present the in vitro characterisation of a Gd3+-based contrast agent that responds to Zn2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd3+-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Meios de Contraste
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2023
Tipo de documento:
Article