Ophthalmic manifestations of Whipple's disease.
Curr Opin Ophthalmol
; 35(1): 83-88, 2024 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-37830937
ABSTRACT
PURPOSE OF REVIEW Whipple's disease is an infectious cause of uveitis that may present with nonspecific findings of intraocular inflammation, which can precede the development of neurologic symptoms and signs. Whipple's disease, then, may evade consideration in the differential diagnosis for uveitis. RECENT FINDINGS:
Molecular tests can be helpful in identifying the presence of Tropheryma whipplei from ocular specimens. The application of metagenomic sequencing for ocular specimens is promising, as it offers the opportunity to identify the pathogen when suspicion for an intraocular infection is high. Whipple's disease demonstrates the ability to abrogate the host immune response, which gives some insight into its pathogenesis.SUMMARY:
Whipple's disease should be suspected in patients who have uveitis refractory to anti-inflammatory therapy. Knowledge of this important pathogen can help direct the timely implementation of diagnostic testing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uveíte
/
Doença de Whipple
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Ophthalmol
Ano de publicação:
2024
Tipo de documento:
Article