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Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.
Bahrani, Ahmed A; Abner, Erin L; DeCarli, Charles S; Barber, Justin M; Sutton, Abigail C; Maillard, Pauline; Sandoval, Francisco; Arfanakis, Konstantinos; Yang, Yung-Chuan; Evia, Arnold M; Schneider, Julie A; Habes, Mohamad; Franklin, Crystal G; Seshadri, Sudha; Satizabal, Claudia L; Caprihan, Arvind; Thompson, Jeffrey F; Rosenberg, Gary A; Wang, Danny J J; Jann, Kay; Zhao, Chenyang; Lu, Hanzhang; Rosenberg, Paul B; Albert, Marilyn S; Ali, Doaa G; Singh, Herpreet; Schwab, Kristin; Greenberg, Steven M; Helmer, Karl G; Powel, David K; Gold, Brian T; Goldstein, Larry B; Wilcock, Donna M; Jicha, Gregory A.
Afiliação
  • Bahrani AA; Department of Neurology, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Abner EL; Sanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • DeCarli CS; Sanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Barber JM; Department of Epidemiology & Environmental Health, University of Kentucky, College of Public Health, Lexington, KY, USA.
  • Sutton AC; Department of Neurology, University of California, Davis, CA, USA.
  • Maillard P; Sanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Sandoval F; Sanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Arfanakis K; Department of Neurology, University of California, Davis, CA, USA.
  • Yang YC; Department of Neurology, University of California, Davis, CA, USA.
  • Evia AM; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Schneider JA; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
  • Habes M; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Franklin CG; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Seshadri S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
  • Satizabal CL; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  • Caprihan A; Research Imaging Institute, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Thompson JF; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Rosenberg GA; Research Imaging Institute, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Wang DJJ; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Jann K; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.
  • Zhao C; The Mind Research Network, Albuquerque, NM, USA.
  • Lu H; The Mind Research Network, Albuquerque, NM, USA.
  • Rosenberg PB; Center for Memory and Aging, University of New Mexico, Health Sciences Center, Albuquerque, NM, USA.
  • Albert MS; Departments of Neurology and Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Ali DG; Departments of Neurology and Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Singh H; Departments of Neurology and Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Schwab K; Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Greenberg SM; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Helmer KG; Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
  • Powel DK; Sanders-Brown Center on Aging, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Gold BT; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Goldstein LB; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Wilcock DM; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Jicha GA; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
J Alzheimers Dis ; 96(2): 683-693, 2023.
Article em En | MEDLINE | ID: mdl-37840499
ABSTRACT

BACKGROUND:

White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker for clinical trials designed to address vascular cognitive-impairment and dementia and Alzheimer's Disease.

OBJECTIVE:

Conducting multi-site cross-site inter-rater and test-retest reliability of the MarkVCID white matter hyperintensity growth and regression protocol.

METHODS:

The NINDS-supported MarkVCID Consortium evaluated a neuroimaging biomarker developed to track WMH change. Test-retest and cross-site inter-rater reliability of the protocol were assessed. Cognitive test scores were analyzed in relation to WMH changes to explore its construct validity.

RESULTS:

ICC values for test-retest reliability of WMH growth and regression were 0.969 and 0.937 respectively, while for cross-site inter-rater ICC values for WMH growth and regression were 0.995 and 0.990 respectively. Word list long-delay free-recall was negatively associated with WMH growth (p < 0.028) but was not associated with WMH regression.

CONCLUSIONS:

The present data demonstrate robust ICC validity of a WMH growth/regression protocol over a one-year period as measured by cross-site inter-rater and test-retest reliability. These data suggest that this approach may serve an important role in clinical trials of disease-modifying agents for VCID that may preferentially affect WMH growth, stability, or regression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Vascular / Doença de Alzheimer / Disfunção Cognitiva / Substância Branca Limite: Humans Idioma: En Revista: J Alzheimers Dis Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demência Vascular / Doença de Alzheimer / Disfunção Cognitiva / Substância Branca Limite: Humans Idioma: En Revista: J Alzheimers Dis Ano de publicação: 2023 Tipo de documento: Article