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Regio-specific enzymatic glucosylation of triterpenoids from Antrodia camphorata and their biological activities.
Su, Hui-Fei; Li, Bin; Yi, Yang; Zhang, Meng; Yu, Rong; Bao, Yang-Oujie; Chen, Kuan; Ye, Min.
Afiliação
  • Su HF; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Li B; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Yi Y; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
  • Zhang M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Yu R; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Bao YO; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Chen K; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
  • Ye M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yemin@bjmu.edu.cn.
Org Biomol Chem ; 21(42): 8467-8470, 2023 11 01.
Article em En | MEDLINE | ID: mdl-37842833
ABSTRACT
The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata. Eleven new compounds were obtained from enzymatic reactions. Glucosylation could increase the inhibitory activities against COX-2, and improve the anti-inflammatory activities of Antrodia ergostanes on acute lung injury mice, especially (25R)-antcin C 7-O-ß-D-glucoside.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Polyporales / Antrodia Limite: Animals Idioma: En Revista: Org Biomol Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Polyporales / Antrodia Limite: Animals Idioma: En Revista: Org Biomol Chem Ano de publicação: 2023 Tipo de documento: Article