Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure.
J Cardiovasc Transl Res
; 17(1): 36-55, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37843752
ABSTRACT
The heart is the most energy-demanding organ throughout the whole body. Perturbations or failure in energy metabolism contributes to heart failure (HF), which represents the advanced stage of various heart diseases. The poor prognosis and huge economic burden associated with HF underscore the high unmet need to explore novel therapies targeting metabolic modulators beyond conventional approaches focused on neurohormonal and hemodynamic regulators. Emerging evidence suggests that alterations in metabolic substrate reliance, metabolic pathways, metabolic by-products, and energy production collectively regulate the occurrence and progression of HF. In this review, we provide an overview of cardiac metabolic remodeling, encompassing the utilization of free fatty acids, glucose metabolism, ketone bodies, and branched-chain amino acids both in the physiological condition and heart failure. Most importantly, the latest advances in pharmacological interventions are discussed as a promising therapeutic approach to restore cardiac function, drawing insights from recent basic research, preclinical and clinical studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiopatias
/
Insuficiência Cardíaca
Limite:
Humans
Idioma:
En
Revista:
J Cardiovasc Transl Res
Ano de publicação:
2024
Tipo de documento:
Article