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Associations of age-adjusted coefficient of variation of R-R intervals with autonomic and peripheral nerve function in non-elderly persons with diabetes.
Sugimoto, Kazuhiro; Miyaoka, Hirozumi; Sozu, Takashi; Sekikawa, Naohiro; Wada, Ryota; Watanabe, Yuko; Tamura, Akira; Yamazaki, Toshiro; Ohta, Setsu; Suzuki, Susumu.
Afiliação
  • Sugimoto K; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Miyaoka H; Department of Information and Computer Technology, Tokyo University of Science Graduate School of Engineering, Tokyo, Japan.
  • Sozu T; Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan.
  • Sekikawa N; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Wada R; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Watanabe Y; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Tamura A; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Yamazaki T; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Ohta S; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
  • Suzuki S; Diabetes Center, Ohta Nishinouchi Hospital, Koriyama, Japan.
J Diabetes Investig ; 15(2): 186-196, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37845838
ABSTRACT
AIMS/

INTRODUCTION:

Early diagnosis of diabetes-associated cardiac autonomic neuropathy using the coefficient of variation of R-R intervals (CVRR) may improve outcomes for individuals with diabetes. The present study examined the associations of decreased CVRR at rest and during deep breathing (DB) with other autonomic nerve function parameters. MATERIALS AND

METHODS:

The electronic records of 141 inpatients with diabetes (22-65 years) admitted to our hospital between March 2015 and March 2019 were analyzed retrospectively. After assessment by exclusion criteria, 51 inpatients were included. All inpatients were assessed for peripheral and autonomic nerve function, clinical characteristics, and physical abilities.

RESULTS:

Inpatients with decreased CVRR at rest (n = 9 (17.6%)) and during DB (n = 12 (23.5%)) had a longer duration of known diabetes, a higher prevalence of diabetic retinopathy, lower body mass index (BMI), skeletal mass index (SMI), and knee extension strength, and a higher proportion of impaired standing balance. Decreased CVRR at rest was associated with a greater fall in diastolic BP from supine to standing, higher resting HR, longer QTc, longer time of voiding, and sensory symptoms.

CONCLUSIONS:

Decreased CVRR at rest and during deep breathing was associated with lower BMI, SMI, and knee strength and a higher proportion of impaired standing balance among non-elderly inpatients with diabetes. Decreased CVRR at rest appeared more strongly associated with a greater orthostatic BP decline, higher resting heart rate, longer QTc, lower urinary tract dysfunction, and sensory symptoms than a decreased CVRR during deep breathing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Autônomo / Diabetes Mellitus / Neuropatias Diabéticas Limite: Humans / Middle aged Idioma: En Revista: J Diabetes Investig Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Autônomo / Diabetes Mellitus / Neuropatias Diabéticas Limite: Humans / Middle aged Idioma: En Revista: J Diabetes Investig Ano de publicação: 2024 Tipo de documento: Article