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In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases.
Kerzel, Thomas; Giacca, Giovanna; Beretta, Stefano; Bresesti, Chiara; Notaro, Marco; Scotti, Giulia Maria; Balestrieri, Chiara; Canu, Tamara; Redegalli, Miriam; Pedica, Federica; Genua, Marco; Ostuni, Renato; Kajaste-Rudnitski, Anna; Oshima, Masanobu; Tonon, Giovanni; Merelli, Ivan; Aldrighetti, Luca; Dellabona, Paolo; Coltella, Nadia; Doglioni, Claudio; Rancoita, Paola M V; Sanvito, Francesca; Naldini, Luigi; Squadrito, Mario Leonardo.
Afiliação
  • Kerzel T; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy.
  • Giacca G; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy.
  • Beretta S; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Bioinformatics Core, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Bresesti C; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy.
  • Notaro M; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy.
  • Scotti GM; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Balestrieri C; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Experimental Hematology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Canu T; Preclinical Imaging Facility, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Redegalli M; Pathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Pedica F; Vita Salute San Raffaele University, 20132 Milan, Italy; Pathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Genua M; Genomics of the Innate Immune System Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Ostuni R; Vita Salute San Raffaele University, 20132 Milan, Italy; Genomics of the Innate Immune System Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Kajaste-Rudnitski A; Retrovirus-Host Interactions and Innate Immunity to Gene Transfer, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Oshima M; Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Japan.
  • Tonon G; Vita Salute San Raffaele University, 20132 Milan, Italy; Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Merelli I; Bioinformatics Core, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; National Research Council, Institute for Biomedical Technologies, 20054 Segrate, Italy.
  • Aldrighetti L; Vita Salute San Raffaele University, 20132 Milan, Italy; Hepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Dellabona P; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Coltella N; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Doglioni C; Vita Salute San Raffaele University, 20132 Milan, Italy; Pathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Rancoita PMV; CUSSB University Center for Statistics in the Biomedical Science, Vita Salute San Raffaele University, 20132 Milan, Italy.
  • Sanvito F; Pathology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; GLP Test Facility, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
  • Naldini L; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy. Electronic address: naldini.lugi@hsr.it.
  • Squadrito ML; Targeted Cancer Gene Therapy Unit, San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy; Vita Salute San Raffaele University, 20132 Milan, Italy. Electronic address: squadrito.mario@hsr.it.
Cancer Cell ; 41(11): 1892-1910.e10, 2023 11 13.
Article em En | MEDLINE | ID: mdl-37863068
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Cancer Cell Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Cancer Cell Ano de publicação: 2023 Tipo de documento: Article