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Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation.
Khatib, Muhammad; Zhao, Eric Tianjiao; Wei, Shiyuan; Abramson, Alex; Bishop, Estelle Spear; Chen, Chih-Hsin; Thomas, Anne-Laure; Xu, Chengyi; Park, Jaeho; Lee, Yeongjun; Hamnett, Ryan; Yu, Weilai; Root, Samuel E; Yuan, Lei; Chakhtoura, Dorine; Kim, Kyun Kyu; Zhong, Donglai; Nishio, Yuya; Zhao, Chuanzhen; Wu, Can; Jiang, Yuanwen; Zhang, Anqi; Li, Jinxing; Wang, Weichen; Salimi-Jazi, Fereshteh; Rafeeqi, Talha A; Hemed, Nofar Mintz; Tok, Jeffrey B-H; Chen, Xiaoke; Kaltschmidt, Julia A; Dunn, James C Y; Bao, Zhenan.
Afiliação
  • Khatib M; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Zhao ET; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Wei S; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Abramson A; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Bishop ES; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
  • Chen CH; The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
  • Thomas AL; Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30332, USA.
  • Xu C; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.
  • Park J; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Lee Y; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Hamnett R; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Yu W; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Root SE; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Yuan L; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
  • Chakhtoura D; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
  • Kim KK; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Zhong D; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Nishio Y; Department of Biology, Stanford University, Stanford, CA, USA.
  • Zhao C; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Wu C; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Jiang Y; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Zhang A; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Li J; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Wang W; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Salimi-Jazi F; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Rafeeqi TA; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Hemed NM; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Tok JB; Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48823, USA.
  • Chen X; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Kaltschmidt JA; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Dunn JCY; Department of Surgery/Pediatric Surgery, Stanford University, Stanford, CA, USA.
  • Bao Z; Department of Materials Science and Engineering, Stanford University, Stanford, California 94305, United States.
bioRxiv ; 2023 Oct 03.
Article em En | MEDLINE | ID: mdl-37873341
ABSTRACT
Bioelectronic fibers hold promise for both research and clinical applications due to their compactness, ease of implantation, and ability to incorporate various functionalities such as sensing and stimulation. However, existing devices suffer from bulkiness, rigidity, limited functionality, and low density of active components. These limitations stem from the difficulty to incorporate many components on one-dimensional (1D) fiber devices due to the incompatibility of conventional microfabrication methods (e.g., photolithography) with curved, thin and long fiber structures. Herein, we introduce a fabrication approach, ‶spiral transformation″, to convert two-dimensional (2D) films containing microfabricated devices into 1D soft fibers. This approach allows for the creation of high density multimodal soft bioelectronic fibers, termed Spiral NeuroString (S-NeuroString), while enabling precise control over the longitudinal, angular, and radial positioning and distribution of the functional components. We show the utility of S-NeuroString for motility mapping, serotonin sensing, and tissue stimulation within the dynamic and soft gastrointestinal (GI) system, as well as for single-unit recordings in the brain. The described bioelectronic fibers hold great promises for next-generation multifunctional implantable electronics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article