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The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review.
Klunko, Natalia S; Achmad, Harun; Abdullah, Tamara Muayad; Mohammed, Sami; Saha, Indranil; Salim, Khulood Saadoon; Obaid, Rasha Fadhel; Romero-Parra, Rosario Mireya; Al-Hasnawi, Shaker Shanawa; Al-Janabi, Wissam Hamid; Farhood, Bagher.
Afiliação
  • Klunko NS; Department of Training of Scientific and Scientific-Pedagogical Personnel, Russian New University, Moscow, Russia.
  • Achmad H; Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
  • Abdullah TM; Department of Radiology and Sonar Techniques, Al-Noor University College, Nineveh, Iraq.
  • Mohammed S; Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
  • Saha I; Department of Physics, GLA University, Mathura, Pin- 281406, U.P., India.
  • Salim KS; College of Pharmacology Pharmacy, Al-Bayan University, Baghdad, Iraq.
  • Obaid RF; Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq.
  • Romero-Parra RM; Department of General Studies, Universidad Continental, Lima, Perú.
  • Al-Hasnawi SS; College of Pharmacy, the Islamic University, 54001 Najaf, Iraq.
  • Al-Janabi WH; Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq.
  • Farhood B; Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Curr Radiopharm ; 2023 Oct 24.
Article em En | MEDLINE | ID: mdl-37877507
Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Curr Radiopharm Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Curr Radiopharm Ano de publicação: 2023 Tipo de documento: Article