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HPV38 impairs UV-induced transcriptional activation of the IL-18 pro-inflammatory cytokine.
Ceraolo, Maria Grazia; Romero-Medina, Maria Carmen; Gobbato, Simone; Melita, Giusi; Krynska, Hanna; Sirand, Cecilia; Gupta, Purnima; Viarisio, Daniele; Robitaille, Alexis; Marvel, Jacqueline; Tommasino, Massimo; Venuti, Assunta; Gheit, Tarik.
Afiliação
  • Ceraolo MG; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Romero-Medina MC; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Gobbato S; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Melita G; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Krynska H; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Sirand C; Biotechnology and Cell Signaling (CNRS/Université de Strasbourg, UMR 7242), Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, Illkirch, France.
  • Gupta P; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Viarisio D; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Robitaille A; German Cancer Research Center, Heidelberg, Germany.
  • Marvel J; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
  • Tommasino M; CIRI, Centre International de Recherche en Infectiologie, Université Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Université Lyon, Lyon, France.
  • Venuti A; IRCCS Istituto Tumori Giovanni Paolo II of Bari, Bari, Italy.
  • Gheit T; International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France.
mSphere ; 8(6): e0045023, 2023 Dec 20.
Article em En | MEDLINE | ID: mdl-37877723
ABSTRACT
IMPORTANCE Here, we demonstrate that the direct binding of p53 on the IL-18 promoter region regulates its gene expression. However, the presence of E6 and E7 from human papillomavirus type 38 impairs this mechanism via a new inhibitory complex formed by DNA methyltransferase 1 (DNMT1)/PKR/ΔNp73α, which binds to the region formerly occupied by p53 in primary keratinocytes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Proteína Supressora de Tumor p53 Limite: Humans Idioma: En Revista: MSphere Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Proteína Supressora de Tumor p53 Limite: Humans Idioma: En Revista: MSphere Ano de publicação: 2023 Tipo de documento: Article