Your browser doesn't support javascript.
loading
Myeloid-derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure: Increased levels of MDSCs in recurrent reproductive failure.
Marin, Nabil Subhi-Issa; Fuente-Muñoz, Eduardo de la; Gil-Laborda, Raquel; Villegas, Ángela; Alonso-Arenilla, Bárbara; Cristóbal, Ignacio; Pilar-Suárez, Lydia; Jiménez-Huete, Adolfo; Calvo, Marta; Sarria, Beatriz; Mansilla-Ruiz, Mariló; Ochoa, Juliana; Fernández-Arquero, Miguel; Sánchez-Ramón, Silvia.
Afiliação
  • Marin NS; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Fuente-Muñoz E; Department of Immunology, Ophthalmology, and ENT, School of Medicine, Complutense University School of Medicine, Madrid, Spain.
  • Gil-Laborda R; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Villegas Á; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Alonso-Arenilla B; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Cristóbal I; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Pilar-Suárez L; Department of Obstetrics and Gynecology, Hospital Clínico San Carlos, Madrid, Spain.
  • Jiménez-Huete A; Department of Obstetrics and Gynecology, Hospital Clínico San Carlos, Madrid, Spain.
  • Calvo M; Department of Neurology, Clínica Universidad Navarra, Madrid, Spain.
  • Sarria B; Department of Obstetrics and Gynecology, Hospital Clínico San Carlos, Madrid, Spain.
  • Mansilla-Ruiz M; Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain.
  • Ochoa J; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Fernández-Arquero M; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
  • Sánchez-Ramón S; Department of Immunology, IML and IdISSC, Hospital Clínico San Carlos, Madrid, Spain.
Am J Reprod Immunol ; 90(5): e13783, 2023 11.
Article em En | MEDLINE | ID: mdl-37881123
ABSTRACT

PROBLEM:

Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro-inflammatory state. This study aimed to explore the levels of monocytic-myeloid-derived suppressor cells (M-MDSCs) and regulatory T cells (TReg ) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF. METHOD OF STUDY One hundred and eight non-pregnant women were evaluated 40 RPL, 41 RIF, and 27 fertile healthy controls (HC). A multiparametric flow cytometry approach was utilized to measure and quantify the frequency of M-MDSCs and TReg cells. Cytokine levels in plasma samples were evaluated through a multiplex assay. M-MDSCs levels were significantly higher in RPL and RIF patients compared to HC.

RESULTS:

M-MDSCs levels were significantly higher in RPL (9.4% [7-11.6]) and RIF (8.1% [5.9-11.6]) patients compared to HC (6% [4.2-7.6]). An optimal cut-off of 6.1% for M-MDSCs disclosed a sensitivity of 75.6% and 89.7% and a specificity of 57.7% and 57.7% in RIF and RPL groups, respectively. A significant negative correlation was observed between M-MDSCs and TReg (p = .002, r = -.51).

CONCLUSIONS:

Our preliminary data allowed us to build a predictive model that may aid as a potential diagnostic tool in the clinic. These findings could provide a better understanding of these pathologies and a better definition of patients that could benefit from personalized treatments to promote pregnancy. Additional exploration and confirmation in distinct study groups are needed to fully assess the diagnostic capabilities of this biomarker.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aborto Habitual / Células Supressoras Mieloides Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Reprod Immunol Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aborto Habitual / Células Supressoras Mieloides Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Reprod Immunol Ano de publicação: 2023 Tipo de documento: Article