Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero-Test bile string.

Tai, Guoying; Xia, Fangming; Chen, Cathy; Pereira, Adrian; Pirhalla, Jill; Miao, Xiusheng; Young, Graeme; Beaumont, Claire; Chen, Liangfu

Tai, Guoying; Xia, Fangming; Chen, Cathy; Pereira, Adrian; Pirhalla, Jill; Miao, Xiusheng; Young, Graeme; Beaumont, Claire; Chen, Liangfu.

Afiliação

Tai G; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.
Xia F; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.
Chen C; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.
Pereira A; Drug Metabolism and Pharmacokinetics, GSK, Stevenage, Hertfordshire, UK.
Pirhalla J; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.
Miao X; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.
Young G; Drug Metabolism and Pharmacokinetics, GSK, Ware, Hertfordshire, UK.
Beaumont C; Drug Metabolism and Pharmacokinetics, GSK, Stevenage, Hertfordshire, UK.
Chen L; Drug Metabolism and Pharmacokinetics, GSK, Collegeville, Pennsylvania, USA.

Pharmacol Res Perspect ; 11(6): e1145, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37885335

Assuntos

Barbitúricos; Bile; Humanos; Masculino; Bile/metabolismo; Estudos Cross-Over; Hidrolases/metabolismo

Palavras-chave

daprodustat; excretion; metabolism; metabolite structural identification; oral absorption; quantitative characterizations; radioactivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Barbitúricos / Bile Limite: Humans / Male Idioma: En Revista: Pharmacol Res Perspect Ano de publicação: 2023 Tipo de documento: Article

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