Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons.

Yang, Yalan; Yang, Runwei; Kang, Bowei; Qian, Sheng; He, Xin; Zhang, Xiaochang

Yang, Yalan; Yang, Runwei; Kang, Bowei; Qian, Sheng; He, Xin; Zhang, Xiaochang.

Afiliação

Yang Y; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA.
Yang R; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA.
Kang B; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA.
Qian S; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA.
He X; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA. Electronic address: xinhe@uchicago.edu.
Zhang X; Department of Human Genetics, Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA. Electronic address: xczhang@uchicago.edu.

Cell Rep ; 42(11): 113335, 2023 11 28.

Article em En | MEDLINE | ID: mdl-37889749

Assuntos

Transtorno Autístico; Humanos; Transtorno Autístico/genética; Processamento Alternativo/genética; Splicing de RNA/genética; Isoformas de Proteínas/genética; Éxons/genética; Íntrons/genética; Sítios de Splice de RNA

Palavras-chave

CP: Molecular biology; CP: Neuroscience; RNA-binding protein; alternative splicing; coordinated splicing; de novo mutation; full-length transcripts; retained intron; scIso-seq; scRNA-seq; splice isoform; uncatalogued isoform

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Autístico Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article

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