Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2.

Pidathala, Shabareesh; Liao, Shuyun; Dai, Yaxin; Li, Xiao; Long, Changkun; Chang, Chi-Lun; Zhang, Zhe; Lee, Chia-Hsueh

Pidathala, Shabareesh; Liao, Shuyun; Dai, Yaxin; Li, Xiao; Long, Changkun; Chang, Chi-Lun; Zhang, Zhe; Lee, Chia-Hsueh.

Afiliação

Pidathala S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Liao S; State Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China.
Dai Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Li X; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Long C; State Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China.
Chang CL; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhang Z; State Key Laboratory of Membrane Biology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing, China. zzhang01@pku.edu.cn.
Lee CH; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. chiahsueh.lee@stjude.org.

Nature ; 623(7989): 1086-1092, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37914936

Assuntos

Neurotransmissores; Reserpina; Serotonina; Tetrabenazina; Proteínas Vesiculares de Transporte de Monoamina; Humanos; Inibidores da Captação Adrenérgica/química; Inibidores da Captação Adrenérgica/farmacologia; Transporte Biológico/efeitos dos fármacos; Microscopia Crioeletrônica; Neurotransmissores/química; Neurotransmissores/farmacologia; Reserpina/química; Reserpina/farmacologia; Serotonina/metabolismo; Transmissão Sináptica; Tetrabenazina/química; Tetrabenazina/farmacologia; Proteínas Vesiculares de Transporte de Monoamina/antagonistas & inibidores; Proteínas Vesiculares de Transporte de Monoamina/química; Proteínas Vesiculares de Transporte de Monoamina/metabolismo; Proteínas Vesiculares de Transporte de Monoamina/ultraestrutura; Especificidade por Substrato/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Reserpina / Tetrabenazina / Serotonina / Neurotransmissores / Proteínas Vesiculares de Transporte de Monoamina Limite: Humans Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article

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