The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Front Biosci (Landmark Ed)
; 28(10): 256, 2023 10 20.
Article
em En
| MEDLINE
| ID: mdl-37919076
ABSTRACT
Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine. Millions of editing sites have been identified in different species and, based on abnormal editing observed in various disorders, it is intuitive to conclude that RNA editing is both functional and adaptive. In this review, we propose the following major points (1) "Function/functional" only represents a molecular/phenotypic consequence and is not necessarily connected to "adaptation/adaptive"; (2) Adaptive editing should be judged in the light of evolution and emphasize advantages of temporal-spatial flexibility; (3) Adaptive editing could, in theory, be extended from nonsynonymous sites to all potentially functional sites. This review seeks to conceptually bridge the gap between molecular biology and evolutionary biology and provide a more objective understanding on the biological functions and evolutionary significance of RNA editing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Edição de RNA
Limite:
Animals
Idioma:
En
Revista:
Front Biosci (Landmark Ed)
Ano de publicação:
2023
Tipo de documento:
Article