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GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential.
Dharavath, Ravinder Naik; Pina-Leblanc, Celeste; Tang, Victor M; Sloan, Matthew E; Nikolova, Yuliya S; Pangarov, Peter; Ruocco, Anthony C; Shield, Kevin; Voineskos, Daphne; Blumberger, Daniel M; Boileau, Isabelle; Bozinoff, Nikki; Gerretsen, Philip; Vieira, Erica; Melamed, Osnat C; Sibille, Etienne; Quilty, Lena C; Prevot, Thomas D.
Afiliação
  • Dharavath RN; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada.
  • Pina-Leblanc C; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada.
  • Tang VM; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Sloan ME; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada.
  • Nikolova YS; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Pangarov P; Addiction Division, CAMH, Toronto, ON, Canada.
  • Ruocco AC; Division of Neurosciences and Clinical Translation, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Shield K; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Voineskos D; Institute of Mental Health Policy Research, CAMH, Toronto, ON, Canada.
  • Blumberger DM; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada.
  • Boileau I; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Bozinoff N; Addiction Division, CAMH, Toronto, ON, Canada.
  • Gerretsen P; Division of Neurosciences and Clinical Translation, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Vieira E; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, ON, Canada.
  • Melamed OC; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Sibille E; Institute of Mental Health Policy Research, CAMH, Toronto, ON, Canada.
  • Quilty LC; Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada.
  • Prevot TD; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Front Neural Circuits ; 17: 1218737, 2023.
Article em En | MEDLINE | ID: mdl-37929054
ABSTRACT
Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and economic costs, and leads to approximately 3 million global deaths yearly. Alcohol use disorder (AUD) includes various drinking behavior patterns that lead to short-term or long-lasting effects on health. Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the intensity and duration of alcohol consumption. A small number of interventions have been developed that target the GABAergic system, but there are promising future therapeutic avenues to explore. This review provides an overview of the impact of alcohol on the GABAergic system, the current interventions available for AUD that target the GABAergic system, and the novel interventions being explored that in the future could be included among first-line therapies for the treatment of AUD.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Alcoolismo Limite: Humans Idioma: En Revista: Front Neural Circuits Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Base de dados: MEDLINE Assunto principal: Alcoolismo Limite: Humans Idioma: En Revista: Front Neural Circuits Ano de publicação: 2023 Tipo de documento: Article