Impact of proteinuria on long-term prognosis in patients with coronary artery disease.
J Cardiovasc Med (Hagerstown)
; 24(12): 900-905, 2023 12 01.
Article
em En
| MEDLINE
| ID: mdl-37942791
ABSTRACT
BACKGROUND:
This study aimed to investigate the association between proteinuria and long-term prognosis in patients with coronary artery disease.METHODS:
This was a single-center observational study. A total of 1351 patients were identified who underwent percutaneous coronary intervention, and whose urine data were available. Patients were divided into two groups according to the presence (nâ=â245) or absence (nâ=â1106) of proteinuria. All-cause and cardiovascular deaths were primarily evaluated.RESULTS:
The prevalence rates of hypertension and diabetes were significantly higher, and the baseline estimated glomerular filtration rate (eGFR) was lower in patients with proteinuria than in those without proteinuria. During the median follow-up of 4.1âyears (interquartile range, 1.7-6.8âyears), the occurrences of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria. Multivariable Cox regression analysis indicated that the presence of proteinuria was a significant predictor of cardiovascular death as well as age, BMI, reduced eGFR, and left ventricular ejection fraction. When stratified into four groups based on eGFR category (eGFR <60 or ≥60âml/min/1.73âm2) and absence or presence of proteinuria, the incidence rates of all-cause and cardiovascular deaths were highest in patients with proteinuria and eGFR less than 60âml/min/1.73âm2. Furthermore, the incidence rates of all-cause and cardiovascular deaths were significantly higher in patients with proteinuria among both diabetic and nondiabetic patients.CONCLUSION:
Proteinuria is associated with the long-term prognosis, and all-cause and cardiovascular deaths in patients with coronary artery disease, regardless of eGFR and the presence or absence of diabetes mellitus.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Doenças Cardiovasculares
Limite:
Humans
Idioma:
En
Revista:
J Cardiovasc Med (Hagerstown)
Ano de publicação:
2023
Tipo de documento:
Article