Influence of previous Zika virus infection on acute dengue episode.
PLoS Negl Trop Dis
; 17(11): e0011710, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37943879
ABSTRACT
BACKGROUND:
The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. METHODOLOGY/PRINCIPALFINDINGS:
We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. CONCLUSIONS/SIGNIFICANCE:
Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Dengue
/
Vírus da Dengue
/
Zika virus
/
Infecção por Zika virus
Limite:
Humans
Idioma:
En
Revista:
PLoS Negl Trop Dis
Ano de publicação:
2023
Tipo de documento:
Article