Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.

O'Donnell, Valerie B; Schebb, Nils H; Milne, Ginger L; Murphy, Michael P; Thomas, Christopher P; Steinhilber, Dieter; Gelhaus, Stacy L; Kühn, Hartmut; Gelb, Michael H; Jakobsson, Per-Johan; Blair, Ian A; Murphy, Robert C; Freeman, Bruce A; Brash, Alan R; FitzGerald, Garret A

O'Donnell, Valerie B; Schebb, Nils H; Milne, Ginger L; Murphy, Michael P; Thomas, Christopher P; Steinhilber, Dieter; Gelhaus, Stacy L; Kühn, Hartmut; Gelb, Michael H; Jakobsson, Per-Johan; Blair, Ian A; Murphy, Robert C; Freeman, Bruce A; Brash, Alan R; FitzGerald, Garret A.

Afiliação

O'Donnell VB; Systems Immunity Research Institute, School of Medicine, Cardiff University, CF14 4XN, Cardiff, Wales, UK. O-donnellvb@cardiff.ac.uk.
Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences University of Wuppertal, Gausstraße 20, 42119, Wuppertal, Germany.
Milne GL; Division of Clinical Pharmacology, Vanderbilt University, 502A Robinson Research Building, Nashville, TN, 37232-6602, USA.
Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.
Thomas CP; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, CF10 3AT, UK.
Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.
Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Kühn H; Institute of Biochemistry, University Medicine Berlin - Charité, Berlin, Germany.
Gelb MH; Department of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Jakobsson PJ; Rheumatology Unit, Dep. of Medicine, Solna, Karolinska Institutet & Karolinska University Hospital, Stockholm, Sweden.
Blair IA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Murphy RC; Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045, USA.
Freeman BA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Brash AR; Department of Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
FitzGerald GA; Institute for Translational Medicine and Therapeutics, Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA, 19104, USA. garret@upenn.edu.

Nat Commun ; 14(1): 7172, 2023 11 09.

Article em En | MEDLINE | ID: mdl-37945602

Assuntos

Ácidos Docosa-Hexaenoicos; Inflamação; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Docosa-Hexaenoicos / Inflamação Limite: Humans Idioma: En Revista: Nat Commun Ano de publicação: 2023 Tipo de documento: Article

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