Beta-blocker use and survival after pancreatic cancer surgery: A nationwide population-based cohort study.
Pharmacoepidemiol Drug Saf
; 33(1): e5726, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37946571
ABSTRACT
PURPOSE:
We examined the association between use of beta-blockers and survival in pancreatic cancer patients after curative-intent surgery.METHODS:
Using Danish healthcare registries, we conducted a population-based cohort study of all patients undergoing curative-intent surgery for pancreatic cancer in Denmark 1997-2021. We defined beta-blocker use according to exposure before surgery as current (≤90 days), recent (91-365 days), or former (366-730 days) use, requiring at least one filled prescription. Patients were followed from the date of surgery for up to 5 years. We used Cox regression to compute hazard ratios (HRs) of deaths with 95% confidence intervals (CIs), adjusting for age, sex, year of diagnosis, cardiovascular disease, diabetes, liver disease, alcohol, and smoking. We also conducted an active comparator analysis, where we used angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers as comparators instead of nonusers.RESULTS:
We included 2592 patients, of which 16.7% were beta-blocker users. Median survival for the entire population was 24.4 months. Beta-blocker use was associated with increased mortality (adjusted HR 1.18; 95% CI 1.04-1.34). This was evident in current (adjusted HR 1.19; 95% CI 1.02-1.38) and recent (adjusted HR 1.29; 95% CI 1.04-1.59) but not former (adjusted HR 0.91; 95% CI 0.64-1.43) users. In the active comparator analysis, the association between beta-blocker exposure and mortality attenuated slightly (adjusted HR 1.12; 95% CI 0.93-1.35).CONCLUSIONS:
We observed an association between beta-blocker use and increased mortality in patients operated for pancreatic cancer. Findings are likely explained by confounding by indication.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Antagonistas Adrenérgicos beta
Limite:
Humans
Idioma:
En
Revista:
Pharmacoepidemiol Drug Saf
Ano de publicação:
2024
Tipo de documento:
Article